Photo-driven upconversion in NaYF4:Yb,Er@chitosane particles for cancer cells bioimaging

Lanthanide doped up-converting nanoparticles (UCNPs) have significant role in biomedical field, especially in cell imaging and target drug delivery, due to their convenient luminescent properties. For that purpose UCNPs should have the specific morphological and luminescent characteristics. In this study the biocompatible NaYF4:Yb,Er@Chitosane particles were synthesized through one-step hydrothermal synthesis. Obtained particles were characterized in detail using X-ray powder diffraction (XRPD), Fourier-transform infrared (FTIR) spectroscopy, field emission scanning and transmission electron microscopy (FESEM and TEM) and photoluminesce measurement (PL). Structural refinement data show the presence of cubic (Fm-3m) phase in spherical shaped nanoparticles size up to 200 nm, while the FTIR analysis revealed the presence of chitosan on the particle surface which have no influence on the luminescence efficiency of the UCNPs. Cytotoxicity as well as cell labeling capability of synthesized UCNPs were tested in vitro on the human gingival fibroblasts (HGF) and head and neck squamous carcinoma cells (HNSCC). The results show excellent biocompatibility against HGF, and successful in- vitro visualization of HNSCC cell cultures upon 980 nm laser irradiation. 

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Author:Ivana Dinić, Aleksandra Đukić Vuković, Marko Nikolić, Olivera Milošević, Lidija Mančić
Parent Title (English):Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia
Publisher:Institute of Technical Sciences of SASA
Place of publication:Belgrade
Editor:Smilja Marković
Document Type:Conference Proceeding
Date of Publication (online):12.05.2017
Year of first Publication:2017
Tag:NaYF4:Yb,Er@chitosane; luminescence; nanoparticles
First Page:2
Last Page:2
Institutes:Institute of Technical Sciences of the Serbian Academy of Sciences and Arts
University of Belgrade, Faculty of Technology and Metallurgy
University of Belgrade, Faculty of Chemistry
open_access (DINI-Set):
Collections:Young Researchers' Conference "Materials Science and Engineering"
Conference abstracts
MESTD Projects 2011-2017:III 45020 - Materials of reduced dimensions for efficient light absorption and energy conversion
Licence (English):License LogoCreative Commons - Attribution-Noncommercial-No Derivative Works 3.0 Serbia